Figure 3. Pindolol, amantadine, and metformin are all substrates of the renal uptake transporter OCT2 (influx ratio >2 under at least one set of in vitro assay conditions); however, one could easily obtain a false negative result by arbitrarily selecting a single set of conditions for screening. This can be avoided by a test matrix of several time points (left hand panel) and concentrations (right hand panel)..
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